Dr. Raimond L. Winslow is a leader in the study of cardiovascular function through development and application of mathematical and computational models based on experimental data. His work on cardiovascular systems biology includes modeling of sub-cellular processes such as beta-adrenergic signaling, mitochondrial energy production and excitation-contraction coupling, as well as integrative modeling of cell and tissue function. He is also recognized for his work in the areas of biomedical data organization and integration and biomedical high-performance computing. Dr. Winslow is Director of the Donald W. Reynolds Cardiovascular Clinical Research Center Bioinformatics Core. He is also Director of the Center for Cardiovascular Bioinformatics & Modeling, Associate Director of the Whitaker Biomedical Engineering Institute and Director of the Biomedical Engineering PhD Training Program. Dr. Winslow is a Professor in the Department of Biomedical Engineering, with joint appointments in the Departments of Computer Science, Electrical and Computer Engineering and the Division of Biomedical Informatics.

Selected recent publications include:

Yung, C., Tomaselli, G. T., and Winslow, R. L. (2003). Gene Expression Profiles in End-Stage Human Idiopathic Dilated Cardiomyopathy: Altered Expression of Apoptotic and Cytoskeletal Genes. Genomics, in press.

Winslow, R. L. and Boguski, M. S. (2003). Genome Informatics: Current status and future prospects. Circ. Res., 2: 950-952.

Greenstein, J. and Winslow, R. L. (2002). An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release. Biophys. J., 83: 2918-2945.

Cortassa,S., Aon, M. A., Marban, E., Winslow, R. L. and O’Rourke, B. (2002). An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys. J. 84: 2734-2755.

Bober, M., Wiehe, K., Yung, C., Suzek, T. O., Lin, M., Baumgartner Jr., W. and Winslow, R. L. (2002). CaGE: Cardiac Gene Expression Knowledgebase. Bioinformatics, 18(7): 1013-1014.

Mazhari,R., Green stein, J., Winslow, R.L., Marban, E., and Nuss, H.B. (2001). Quantitative analysis of molecular interactions between two long QT syndrome gene products, KCNH2 and KCNE2. Circ. Res., 89: 33-38.

Scollan, D., Holmes, A., Jiang, Z. and Winslow, R. L.(2000). Reconstuction of cardiac ventricular geometry and fiber orientation using magnetic resonance imaging.  Ann. Biomed. Eng., 28(8): 934-944.

Winslow, R. L., Rice, J. J., Jafri, S., Marban, E., and O’Rourke, B. (1999). Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure II: Model Studies. Circ. Res. 84: 571-586.